Should be taken with food: Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.
Type 2 DM patients; closely monitor antidiabetic treatment. Increased risk for GI adverse reactions if taken w/ a meal very high in fat. Distribute daily intake of fat over 3 main meals. Rectal bleeding. Hyperoxaluria & oxalate nephropathy leading sometimes to renal failure, especially in patients w/ underlying chronic kidney disease &/or vol depletion. Rare occurrence of hypothyroidism &/or reduced control of hypothyroidism may occur. Severe liver injury. Monitor renal function in patients at risk for renal impairment. Concomitant use w/ anticonvulsive treatment; antiretroviral medicines for HIV; ciclosporin. Additional contraceptive method is recommended. Monitor coagulation parameters in patients treated w/ concomitant oral anticoagulants.
Decreased plasma levels of ciclosporin. Avoid co-administration w/ acarbose. Monitor INR when co-administered w/ warfarin or other anticoagulants. May impair absorption of fat-soluble vit A, D, E & K. May unbalance anticonvulsive treatment. May potentially reduce absorption of antiretroviral medicines for HIV. Slight decrease in plasma levels of amiodarone. Possible decrease in absorption of iodine salts &/or levothyroxine. May indirectly reduce availability of OCs.
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